HomeLab DynamicsResearchOur StaffRequest Free Biopsy Kits
CPC 15
View A Different CPC:  
A 32 year old female presented to an oral surgeon with slight buccal expansion of the mandible. Radiographs revealed a lesion causing divergence of the apices of the two lower left bicuspids. The tumor was well-delineated, exhibited inferior cortical expansion and showed evidence of patchy deposits of calcifications.

Differential Diagnosis:

  1. Cementifying or Ossifying Fibroma
  2. Calcifying Odontogenic Cyst
  3. Calcifying Epithelial Odontogenic Tumor

The round appearance, inferior cortical expansion and presence of hard deposits favor a diagnosis of cementifying or ossifying fibroma although other calcifying lesions should be considered.


Slide 1 (low power, H&E). This slide shows variously sized calcified deposits (you can not tell whether it is bone or cementum at this power) with a cellular connective tissue background.

Slide 2 (high power, H&E). The hard material contains osteocytes and appears to be bone. These bone trabeculae are bordered by scattered osteoblasts. The supporting connective tissue is cellular and contains uniform basophilic nuclei.

Diagnosis: Ossifying Fibroma