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 This
18 year old female was noted to have a radiolucent lesion involving the
right mandible. It appeared well-delineated, was asymptomatic, and the
associated teeth were vital.
Histology:
Diagnosis: Giant Cell Granuloma, central
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Differential Diagnosis:
Slide 1 (medium power, H&E). The center of this field shows collections of multinucleated giant cells. (The haphazard arrangement of the nuclei indicate that they are osteoclastic or foreign body type giant cells.) A significant amount of hemorrhage is seen, some of it is related to the surgery while the rest is an inherent part of the lesion. The supporting stroma is cellular and fibroblastic. Note the osteoid which is being formed in the upper right portion of this slide.
Slide 2 (high power, H&E). This slide demonstrates a closely knit focus of
giant cells and areas of hemorrhage.